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What is Sirtuin 6? 

If you’re interested in maintaining good health as you age, you may have come across Sirtuin supplements. Sirtuins are a group of proteins that help regulate a variety of cellular processes in the body, including inflammation and metabolism. But what exactly are Sirtuin supplements, and how do they affect your health? In this article, we’ll explore the science behind Sirtuins and their potential benefits for your health.

The Basics of Sirtuin 6

Sirtuin 6, or SIRT6, is a protein that plays a critical role in regulating several cellular processes, including DNA repair, metabolism, and inflammation. SIRT6 belongs to a family of proteins called sirtuins, which are known for their ability to regulate cellular processes by modifying other proteins. Sirtuin 6 is a protein that is mainly located in the centre of cells and has a job of removing a small chemical group called “acetyl” from other proteins called “histones”. Removing the acetyl group from histones has positive effects on the regulation of gene expression. Histones are the proteins around which DNA is wrapped, and modifications to these proteins can have a significant impact on how genes are expressed and can ultimately affect the function and behaviour of cells.


How Do Supplements Activate Sirtuin 6?

Activating SIRT6 protein has been revolutionary in the way we approach various diseases such as cancer, diabetes, and neurodegenerative diseases. Studies show that such activators can also increase the activity of other Sirtuins, offering even more health benefits. However, not all activators are equal, and the wrong supplement could be ineffective or even dangerous. For this reason, it’s essential to ensure you get the best SIRT6 Activator available – which is’s SIRT6 Activator, tested for its effectiveness at activating Sirtuin 6 by one of the professors on their board, Vera Gorbunova. Professor Vera Gorbunova is a co-director at the Rochester Aging Research Center and the world’s leading scientist on Sirtuins.

SIRT6 Activator Supplements

Our SIRT6 Activator supplement is an all-natural product derived from seaweed, and the only supplement in the world that is proven to activate Sirtuin 6. The strain of seaweed is called Fucus Vesiculous. Unfortunately, the majority of the Fucus Vesiculosus tested from all over the world either inhibited SIRT6 or did not have the beneficial effects that are desired. This is why DoNotAge has protected this ingredient so that you know the product you receive activates Sirtuin 6. Countries where people consume the most seaweed, such as Japan and South Korea, also have some of the highest life expectancies in the world. Seaweed has been found to provide a variety of health benefits that promote longevity. For instance, it can boost the immune response to flu vaccines in older adults, lower inflammation levels, and even improve the survival rates of cancer patients who are undergoing chemotherapy.


Sirtuin 6 Benefits

SIRT6 is essential for DNA repair and energy production by increasing the efficiency of ATP production. It maintains genomic stability in the brain and has potential therapeutic value for Alzheimer’s disease and neurodegeneration. Additionally, SIRT6 has other health benefits such as reducing inflammation, improving insulin sensitivity, and promoting healthy ageing.

Sirtuin 6 Has Anti-ageing Properties

SIRT6 has been shown to be involved in a variety of processes that contribute to ageing, such as DNA repair and inflammation. By activating SIRT6, the ageing process can be slowed down, and age-related diseases can be prevented. In a recent study, mice that were given a SIRT6 activator lived far longer and healthier than their untreated counterparts.

Improved Glucose and Lipid Metabolism

Sirtuin 6 regulates insulin sensitivity, glucose uptake, and lipid synthesis in adipose tissue and liver, which can prevent metabolic disorders such as type 2 diabetes and obesity. Insulin helps to regulate glucose levels in the blood by allowing cells to take up glucose for energy. By increasing insulin secretion, Sirtuin 6 can help to improve glucose metabolism. The way it increases glucose uptake is by activating AMP-activated protein kinase (AMPK), which is a key regulator of energy metabolism, and promotes the breakdown of fats into energy in the fast-glycolytic and aerobic energy systems (type 2a and 2b energy systems).

Sirtuin 6 has the power to counteract SREBP, a major molecule responsible for the creation of cholesterol and triglycerides in the liver. By minimising the activity of this molecule, this valuable protein can help protect the body from the effects that the production of these substances can bring. This invaluable asset for our health can limit the danger of metabolic diseases by drastically decreasing the amount of cholesterol and triglycerides build-ups. Additionally, Sirtuin 6 plays a huge part in fat metabolism by preserving a healthy level of fat production and extraction. Therefore, Sirtuin 6 is an undeniable aid in preserving an orderly and regulated metabolism, making it a valuable ally.

Sirtuin 6 Improves Cardiovascular Function

Sirtuin 6 is a protein that has positive effects on cardiovascular health, with evidence that it can improve the growth of new blood vessels, relax existing vessels, and bolster the potency of heart contractions. It has a direct effect on lowering the risk of heart failure. By manipulating these, Sirtuin 6 provides a concrete example of the power of science in improving and extending life.

Protects Against Heart Failure

SIRT6 has been shown to protect against heart failure by improving cardiac function and reducing cardiac hypertrophy, a condition in which the heart becomes enlarged and less efficient. SIRT6 can also reduce fibrosis, a process in which excess connective tissue forms in the heart, which can impair its function.

Sirtuin 6 Plays a Role in Cancer Prevention

SIRT6, has also been found to lower the risk of developing cancer. It has been the subject of various experiments focusing on its role in managing the activity of another protein named HIF-1 alpha. It is believed that when HIF-1 alpha is highly active, it causes cells to abnormally grow and turn cancerous; conversely, SIRT6 is known to work as a deterrent, suppressing mutations and preventing the spread of cancerous cells.

Our supplier DoNotAge is currently running a long-term human trial in people that have already had chemotherapy to prove that SIRT6Activator prevents the recurrence of cancer.

In addition, Sirtuin 6 has been linked to the maintenance of telomeres. Telomeres are protective structures located at the end of chromosomes. It does this by assisting in keeping them at the proper length. Should telomeres be too short, cells can become destabilised and be led down the path toward cancer. By regulating their length, Sirtuin 6 works to keep cells healthy and cancer-free.


Sirtuin 6 Supplement Studies

One study studied Sirtuin 6 deficient mice. They discovered that these small mice developed abnormalities such as profound lymphopenias, loss of subcutaneous fat, lorfdokyphosis, and severe metabolic defects at just 2-3 weeks old, eventually dying at 4 weeks old. They concluded that one function of Sirtuin 6 is to promote normal DNA repair, and that Sirtuin 6 loss leads to abnormalities in mice that overlap with ageing-associated degenerative processes.


Clinical Trials and Future Prospects

There are currently several clinical trials underway to investigate the potential of SIRT6 activators for treating age-related diseases such as Alzheimer’s and metabolic disorders such as diabetes.

In the future, Sirtuin 6 activators could be used as a natural alternative to traditional anti-ageing treatments such as Botox and fillers. They could also be used to treat a variety of age-related diseases, from cancer to metabolic disorders.


Conclusion on Sirtuin 6 Activator Supplements

In conclusion, Sirtuin 6 is a protein that plays a critical role in regulating several cellular processes, including DNA repair, metabolism, and inflammation. Our Sirtuin 6 activator supplement works by activating Sirtuin 6. Once this is activated Sirtuin 6 can prevent age-related diseases and slows down the ageing process, improves glucose and lipid metabolism, reduces inflammation, and promotes healthy ageing. Incorporating powerful but natural products such as SIRT6Activator into your diet is also be beneficial for your overall health and lifespan. It’s essential to ensure you get the best Sirtuin 6 activator available, tested for its effectiveness at activating Sirtuin 6 by the specialists.


Why we sell DoNotAge produced Sirt6?

Their SIRT6 has been tested by renowned longevity professor Vera Gorbunova who is also a co-director at the Rochester Aging Research Center and the world’s leading scientist on Sirtuins. The majority of the Fucus Vesiculosus they tested from all over the world inhibited SIRT6 and did not have the beneficial effects that was desired. This is why they have protected this ingredient so that you know the product you receive activates Sirtuin 6.

The curation and testing process for this product is extremely long-winded, detailed and laborious. Many samples are procured from all corners of the world, and for each harvested batch, they test for its ability to activate Sirtuin 6. Other supplement companies may not put their products through this rigorous testing process, meaning you could pay for an ineffective supplement.

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